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Maryse LEBRUN

(project leader)

 

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Lebrun team Research.

The Apicomplexa phylum is defined by the presence of an apical complex of organelles that include two specific secretory granules called micronemes and rhoptries. These organelles sequentially release their contents during invasion: microneme proteins contribute to motility, attachment and invasion, while rhoptry proteins contribute to both invasion and subsequent manipulation of host cell functions. Our research is focused on the formation of a structure (the moving junction) which is essential for host cell invasion in both Toxoplasma and Plasmodium, and depends on the cooperation between microneme and rhoptry proteins. We are also interested by the mechanism of secretion of rhoptries, which remains a major conundrum in the field. Finally, we are also investigating lipid kinases that are important for the homeostasis of the apicoplast (a non-photosynthetic plastid important for parasite metabolism), and for intracellular development.


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