dimnp

 

Laboratory Publications

 

 

- 2017 Publications -



Equipe 1 – Catherine BRAUN-BRETON PR UM – Maryse LEBRUN DR INSERM

- Besteiro S. (2017) Autophagy in apicomplexan parasites. Curr Opin Microbiol. 40:14-20 Pubmed

- Nguyen HM, Berry L, Sullivan WJ Jr, Besteiro S. (2017) Autophagy participates in the unfolded protein response in Toxoplasma gondii. FEMS Microbiol Lett. 15;364(15). Pubmed

- Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol. Jun 19;2:17096. Pubmed

- Nguyen HM, El Hajj H, El Hajj R, Tawil N, Berry L, Lebrun M, Bordat Y, Besteiro S. (2017)  Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host.  Cell Microbiol. In press. Pubmed

- Latré de Laté P, Pineda M, Harnett M, Harnett W, Besteiro S, Langsley G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomed J. 40(1):23-30. Pubmed

- Harnett MM, Pineda MA, Latré de Laté P, Eason RJ, Besteiro S, Harnett W, Langsley G. (2017). From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home. Biomed J. 40(1):9-22. Pubmed

- Wein S, Taudon N, Maynadier M, Tran Van Ba C, Margout D, Bordat Y, Fraisse L, Wengelnik K, Cerdan R, Bressolle-Gomeni F, Vial HJ. High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death. Antimicrob Agents Chemother. 2017 Jul  25;61(8). pii: e00352-17. doi: 10.1128/AAC.00352-17.

- Francisco Hilario F, Traoré M, Zwick V, Berry L, Simões-Pires C, Cuendet M, Fantozzi N, Pereira de Freitas R, Maynadier  M, Wein S, Vial H, Wong, YS. Synthesis of an uncharged tetra-cyclopeptide acting as transmembrane carrier: enhanced cellular and nuclear uptake. Organic Letters, 2017, 19(3):612-615.

- Traoré M. D. M.,  Zwick V.,  Simões-Pires C. A., Nurisso A. ,  Issa M.,  Cuendet M., Maynadier M. , Wein S. , Vial H. , Jamet  H. and  Wong Y-S. Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6. ACS Omega, 2017, 2 (4), pp 1550–1562 , DOI: 10.1021/acsomega.6b00481

- Nguyen HM, Berry L, Sullivan WJ Jr, Besteiro S. (2017) Autophagy participates in the unfolded protein response in Toxoplasma gondii. FEMS Microbiol Lett. 15;364(15). Pubmed

- Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol. Jun 19;2:17096. Pubmed

 

- 2016 Publications -

 

Equipe 1 – Catherine BRAUN-BRETON PR UM – Maryse LEBRUN DR INSERM

Nguyen HM, El Hajj H, El Hajj R, Tawil N, Berry L, Lebrun M, Bordat Y, Besteiro S.
Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host.
Cell Microbiol. 2016 Dec 19.

Latré de Laté P, Pineda M, Harnett M, Harnett W, Besteiro S, Langsley G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomed J. 40(1):23-30. Pubmed

Harnett MM, Pineda MA, Latré de Laté P, Eason RJ, Besteiro S, Harnett W, Langsley G. (2017). From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home. Biomed J. 40(1):9-22. Pubmed

Berry L, Chen CT, Reininger L, Carvalho TG, El Hajj H, Morlon-Guyot J, Bordat Y, Lebrun M, Gubbels MJ, Doerig C, Daher W.
The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence.
Cell Microbiol. 2016 Aug;18(8):1106-20.

Lévêque MF, Nguyen HM, Besteiro S.
Repurposing of conserved autophagy-related protein ATG8 in a divergent eukaryote.
Commun Integr Biol. 2016 Jul 1;9(4):e1197447.

Lévêque MF, Berry L, Besteiro S.
An evolutionarily conserved SSNA1/DIP13 homologue is a component of both basal and apical complexes of Toxoplasma gondii.
Sci Rep. 2016 Jun 21;6:27809.

Daher W, Morlon-Guyot J, Alayi TD, Tomavo S, Wengelnik K, Lebrun M.
Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containing protein that binds to the phosphoinositide PI(3,5)P2.
Mol Biochem Parasitol. 2016 May;207(1):39-44.

Braun-Breton C, Abkarian M.
Red Blood Cell Spectrin Skeleton in the Spotlight.
Trends Parasitol. 2016 Feb;32(2):90-2.

Parker ML, Penarete-Vargas DM, Hamilton PT, Guérin A, Dubey JP, Perlman SJ, Spano F, Lebrun M, Boulanger MJ.
Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):398-403.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). [Academic Journal]
Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: In Process; MEDLINE DOI: 10.1080/15548627.2015.1100356


Equipe 2 – Virgine MOLLE DR CNRS

S. Brelle, G. Baronian, S. Huc-Brandt, L.G. Zaki, M. Cohen-Gonsaud, M. Bischoff and V. Molle (2016) Phosphorylation-mediated regulation of the Staphylococcus aureus secreted tyrosine phosphatase PtpA. Biochemical and Biophysical Research Communications 469:619-625.

M. Catel-Ferreira, S. Marti, L. Guillon, L. Jara, G. Coadou, V. Molle, E. Bouffartigues, G. Bou, I. Shalk, T. Jouenne, X. Vila-Farrés and Dé E (2016). The outer membrane porin OmpW of Acinetobacter baumannii is involved in iron uptake and colistin binding. FEBS Letters 590:224-231.

M. Bischoff, S. Brelle, S. Minatelli and V. Molle (2016) Stk1-mediated phosphorylation stimulates the DNA-binding properties of the Staphylococcus aureus SpoVG transcriptional factor. Biochemical and Biophysical Research Communications 473:1223-1228.

A. Gueho, C. Bosmani, N. Gopaldass, V. Molle, T. Soldati and F. Letourneur (2016) Dictyostelium EHD associates with Dynamin and participates in phagosome maturation. Journal of Cell Science 129:2354-2367.

N-H Le, V. Molle, N. Eynard, M. Miras, A. Stella, F. Bardou, S. Galandrin, V. Guillet, G. André-Leroux, M. Bellinzoni, P.Alzari, L. Mourey, O. Burlet-Schiltz, M. Daffé and H. Marrakchi (2016) Ser/Thr phosphorylation regulates the Fatty Acyl-AMP Ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis. Journal of Biological Chemistry 291:22793-22805.

A. K. Sharma, D. Arora, L. K. Singh, A. Gangwal, A. Sajid, V. Molle, Y. Singh, and V. K. Nandicoori (2016) Serine/threonine protein phosphatase PstP of Mycobacterium tuberculosis is necessary for accurate cell division and survival of pathogen. Journal of Biological Chemistry 291:24215-24230.

Le Moigne C, Belon C, Goulard C, Accard G, Bernut A, Pitard B, Gaillard JL, Kremer L, Herrmann JL and Blanc-Potard AB. (2016) MgtC as a host-induced factor and vaccine candidate against Mycobacterium abscessus infection. Infect. Immun. ;84(10):2895-903.

Belon C and Blanc-Potard AB. (2016) Intramacrophage survival for extracellular bacterial pathogens: MgtC as a key adaptive factor. Front Cell Infect Microbiol. doi: 10.3389/fcimb.2016.00052

Belon C, Rosas Olvera M, Vives E, Kremer L, Gannoun-Zaki L, Blanc-Potard AB. (2016) Use of the Salmonella MgtR peptide as an antagonist of the Mycobacterium MgtC virulence factor. Future Microbiol. 11:215-25


Equipe 3 – Michel VIDAL DR CNRS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). [Academic Journal]

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: In Process; MEDLINE DOI: 10.1080/15548627.2015.1100356


Equipe 4 – Andréa PARMEGGIANI PR UM – Ovidiu RADULESCU PR UM

Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation. [Academic Journal]
Gorgoni B; Ciandrini L; McFarland MR; Romano MC; Stansfield I
Publisher: Oxford University Press NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res.

Protein Synthesis Driven by Dynamical Stochastic Transcription. [Academic Journal]
Innocentini GC; Forger M; Radulescu O; Antoneli F
Publisher: Springer Country of Publication: United States NLM ID: 0401404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9602 (Electronic) Linking ISSN: 00928240 NLM ISO Abbreviation: Bull. Math. Biol. Subsets: In Process; MEDLINE DOI: 10.1007/s11538-015-0131-3


Equipe 5 – Georges LUTFALLA DR CNRS

Crystal structure of human S100A8 in complex with zinc and calcium. [Academic Journal]
Lin H; Andersen GR; Yatime L
Publisher: BioMed Central Country of Publication: England NLM ID: 101088689 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6807 (Electronic) Linking ISSN: 14726807 NLM ISO Abbreviation: BMC Struct. Biol. Subsets: In Process; MEDLINE DOI: 10.1186/s12900-016-0058-4

Crystal structure of human S100A8 in complex with zinc and calcium. [Academic Journal]
Haili Lin; Andersen, Gregers Rom; Yatime, Laure
BMC Structural Biology. 6/1/2016, Vol. 16, p1-10. 10p. 2 Diagrams, 2 Charts, 1 Graph. DOI: 10.1186/s12900-016-0058-4

A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage. [Academic Journal]
Faure E; Savy T; Rizzi B; Melani C; Stašová O; Fabrèges D; Špir R; Hammons M; Čúnderlík R; Recher G; Lombardot B; Duloquin L; Colin I; Kollár J; Desnoulez S; Affaticati P; Maury B; Boyreau A; Nief JY; Calvat P; Vernier P; Frain M; Lutfalla G; Kergosien Y; Suret P; Remešíková M; Doursat R; Sarti A; Mikula K; Peyriéras N; Bourgine P
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE DOI: 10.1038/ncomms9674

 

- 2015 Publications -

 

Equipe 1 – Catherine BRAUN-BRETON PR UM – Maryse LEBRUN DR INSERM

De Macêdo JP., Schumann Burkard G., Niemann M., Barrett MP., Vial H., Mäser P., Roditi I., Schneider A., Bütikofer P.(2015) An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS Pathog. May 6;11(5):e1004875. doi: 10.1371/journal.ppat.1004875. eCollection.

Contet A., Pihan E., Lavigne M., Wengelnik K., Maheshwari S., Vial H., Douguet D. & Cerdan R. (2015) Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening., FEBS Letter, Apr 13; 589(9):992-1000. doi: 10.1016/j.febslet.2015.03.003. Epub 2015 Mar 13. PMID: 25771858

Winkler M., Maynadier M., Wein S., Lespinasse MA., Boumis G., Miele AE., Vial H., Wong YS. (2015). Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives. Org Biomol Chem. 2015, 13(7):2064-77. doi: 10.1039/c4ob02459a. PMID: 25519040.

Mbengue A., Vialla E., Berry L., Fall G., Audiger N., Demettre-Verceil E, Boteller D., Braun-Breton C.  (2015) New export pathway in Plasmodium falciparum-infected erythrocytes: role of the parasite group II chaperonin, PfTRiC. Traffic - 16(5):461-475

Besteiro S., Blanc-Potard A., Bonazzi M., Briant L., Chazal N., Cornillot E., Lentini G., Matkovic R., Sanosyan A., Tuaillon E., Van de Perre P.  (2014) Montpellier Infectious Diseases - Pôle Rabelais (MID) 3rd annual meeting. Infect Genet Evol. 2015 Jun;32:161-4.

Besteiro S. (2015) Toxoplasma control of host apoptosis: the art of not biting too hard the hand that feeds you. Microb Cell. 2(6): 178-181

Pihan E., Delgadillo RF., Tonkin ML., Pugnière M., Lebrun M., Boulanger MJ., Douguet D. (2015) Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex. J Comput Aided Mol Des.

Debaisieux S., Lachambre S., Gross A., Mettling C., Besteiro S., Yezid H., Henaff D., Chopard C., Mesnard JM., Beaumelle B. (2015) HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup. Nat Commun.  4;6:6211

Rugarabamu G., Marq JB., Guérin A., Lebrun M., Soldati-Favre D. (2015) Distinct contribution of Toxoplasma gondii rhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion. Mol Microbiol. Apr 2.

Lentini G., Kong-Hap M., El Hajj H., Francia M., Claudet C., Striepen B., Dubremetz JF., Lebrun M.  (2015) Identification and characterization of Toxoplasma SIP, a conserved apicomplexan cytoskeleton protein involved in maintaining the shape, motility and virulence of the parasite. Cell Microbiol. 17(1):62-78.

Morlon-Guyot J., Pastore S., Berry L., Lebrun M., Daher W.  (2015) Toxoplasma gondii Vps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles. Cellular Microbiology, 1157-1178.

Daher W., Morlon-Guyot J., Sheiner L., Lentini G., Berry L., Tawk L., Dubremetz JF., Wengelnik K., Striepen B., Lebrun M. (2015) Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cellular Microbiology, 559-578.

Lévêque M., Berry L., Cipriano M., Nguyen Hoa-Mai., Striepen B., Besteiro S. (2015) Autophagy-related protein ATG8 has a non-canonical function for apicoplast inheritance in Toxoplasma gondii. Mbio. 2015 Oct 27;6(6). pii: e01446-15. doi: 10.1128/mBio.01446-15

Risco-Castillo V., Topçu Selma., Marinach C., Manzon G., Bigorgne A.E., Briquet S., Baudin X., Lebrun M., Dubremetz J.F., and Olivier Silvie.  (2015) Malaria Sporozoites Traverse Host Cells within Transient Vacuoles.  Cell Host & Microbes. In press

 

Equipe 2 – Virgine MOLLE DR CNRS

Bernut A., Belon C., Soscia C., Bleves S., Blanc-Potard AB. Intracellular phase for an extracellular bacterial pathogen: MgtC shows the way. Microbial Cell. In press

Guzzo M., Agrebi R., Espinosa L., Baronian G.,  Molle V., Mauriello E.M., Brochier-Armanet C. and Mignot T. (2015) Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway. PLoS Genetics 20;11(8):e1005460. doi: 10.1371/journal.pgen.1005460.

Belon C., Soscia C., Bernut A., Laubier A., Bleves S., Blanc-Potard AB. (2015) A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens. PLoS Pathog. 11(6):e1004969. doi: 10.1371/journal.ppat.1004969. eCollection

Besteiro S., Blanc-Potard A., Bonazzi M., Briant L., Chazal N., Cornillot E., Lentini G., Matkovic R., Sanosyan A., Tuaillon E., Van de Perre P. Montpellier Infectious Diseases - Pôle Rabelais (MID) 3rd annual meeting (2014). Infect Genet Evol. 2015 Jun;32:161-4.

Baronian G., Ginda K., Berry L., Cohen-Gonsaud M., Zakrzewska-Czerwińska J., Jakimowicz D. And Molle V. (2015) Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system. PLoS One 10:e0119907.

 

Equipe 3 – Michel VIDAL DR CNRS

Blanc L., Papoin J., Debnath G., Vidal M., Amson R., Telerman A., An X., and Mohandas N. (2015) Defective erythropoiesis leads to microcytic anemia in the TSAP6/Steap3 null mouse model. Am. J. Hematol.  Mar;90 (3) : 235-41.doi: 10.1002/ajh.23920

Le Goff  E., Martinand-Mari C., Martin M., Feuillard J., Boublik Y., Godefroy N., Mangeat P., Baghdiguian S. and Cavalli G. (2015)  Enhancer of zeste acts as a major developmental regulator of Ciona intestinalis embryogenesis. Biology Open August 14, doi:10.1242/bio.010835

 

Equipe 4 – Andréa PARMEGGIANI PR UM – Ovidiu RADULESCU PR UM

Sanchez A., Cattoni D., Walter J.-C., Rech J., Parmeggiani A., Nollmann M., Bouet J.-Y. (2015) Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus, Cell Systems, vol. 1 p.163-173

Golushko I.Y., Rochal S.B., Parmeggiani A., Lorman V.L. (2015) Instabilities and shape variation phase transitions in tubular lipid membranes, arXiv preprint arXiv :1501.00258 

Baiesi M., Carlon E., Parmeggiani A. (2015) Fundamental Problems in Statistical Physics XIII Special Issue, Physica A Statistical Mechanics and its Applications 418, 1-5

Ciandrini L. (2015) Molecular motors with a stepping cycle: from theory to experiments.  Proceedings of Traffic and Granular Flow '13, pp 619-627, Springer 

Samal S.S., Grigoriev D., Fröhlich H., Radulescu O. (2015): Analysis of reaction network systems using tropical geometry. In: V.P. Gerdt, W. Koepf, W.M. Seiler, E.V. Vorozhtsov (eds.) Computer Algebra in Scientific Computing, 17th International Workshop (CASC 2015), Lecture Notes in Computer Science, vol. 9301, pp. 422--437. Springer, Aachen, Germany

Radulescu O., Vakulenko S., Grigoriev D. (2015) : Model reduction of biochemical reactions networks by tropical analysis methods. Mathematical Models of Natural Phenomena 10(3), 124-138

Fardin M-A., Radulescu O., Morozov A., Cardoso O., and Lerouge S..  (2015) Stress diffusion in shear banding wormlike micelles. Journal of Rheology, in press

Radulescu O., Samal S.S., Naldi A., Grigoriev D. and Weber A. (2015) Symbolic dynamics of biochemical pathways as finite state machines. 13th International Conference (CMSB 2015), Lecture Notes in Computer Science, in press.

 

Equipe 5 – Georges LUTFALLA DR CNRS

Hirsinger E., Carvalho JE., Chevalier C., Lutfalla G., Nicolas JF., Peyriéras N., Schubert M. (2015) Expression of fluorescent proteins in Branchiostoma lanceolatum by mRNA injection into unfertilized oocytes. J Vis Exp. 12;(95). doi: 10.3791/52042

Madgwick A., Fort P., Hanson PS., Thibault P., Gaudreau M., Lutfalla G., Möröy T., Abou Elela S., Chaudhry‎ B., Elliott DJ., Morris CM & Venables JP (2015) Neural differentiation modulates the vertebrate brain specific splicing program. PLoS One. 10(5):e0125998.

Bernut A., Dupont CM., Sahuquet A., Herrmann JL., Lutfalla G. and Kremer L. (2015)Deciphering and imaging pathogenesis and cording of Mycobacterium abscessus in zebrafish embryos. J Vis Exp. Sep 9;(103).

Nguyen Chi M., Laplace-Builhe B., Travnickova J., Luz-Crawford P., Tejedor G., Phan QT., I Duroux-Richard., Levraud JP., Kissa K., Lutfalla G., Jorgensen C., & Djouad F. (2015) Identification of macrophage subsets in zebrafish larvae: from behaviour to molecular signature. eLife, Jul 8;4:e07288. 

Debaisieux S., Lachambre S., Gross A., Mettling C., Besteiro S., Yezid H., Henaff D., Chopard C., Mesnard JM., Beaumelle B. (2015) HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup. Nat Commun. 2015 Feb 4;6:6211.

 

Equipe 6 – Karima KISSA CR INSERM

Travnickova J., Tran Chau V., Julien E., Mateos-Langerak J., Gonzalez C., Lelièvre E., Lutfalla G., Tavian M., Kissa K. (2015) Primitive macrophages control HSPC mobilization and definitive haematopoiesis. Nat Commun. Feb 17;6:6227.

 

Equipe 7 – Gilles UZE DR CNRS

Zhang, X., Bogunovic, D., Payelle-Brogard, B., Francois-Newton, V., Speer, S., Yuan, C., Volpi., S., Li, Z., Sanal, O., Mansouri, D., Tezcan, I., Rice, G.I., Chen, C., Mansouri, N., Mahdaviani, S-A., Itan, Y., Boisson, B., Okada, S., Zeng, L., Wang, X., Jiang, H., Liu, W., Han, T., Liu, D., Ma., T., Wang, B., Liu, M., Liu, J., Wang, Q.K., Yalnizoglu, D., Radoshevich, L., Uzé, G., Gros, P., Rozenberg, F., Zhang, S-Y., Jouanguy, E., Bustamante, J., García-Sastre, A., Abel, L., Lebon, P., Notarangelo, L.D., Boisson-Dupuis, S., Crow, Y.J., Casanova, J-L. and Pellegrini, S.(2015) Human intracellular ISG15 prevents IFN-α/β over-amplification and auto-inflammation. Nature. 517. 89-93.

Sultanik P-S., Casrouge  A., Alanio C., Mottez E., Rosa-Hézode I., Hézode C., Renard P., Bousquet L., Pelle  P., Uzé G., Pol S., Albert M.L. and Mallet V. J. (2015) Baseline sensitivity of T cells to alpha-interferon correlates with sustained virological response to IFN-based triple therapy in HCV infection. Viral Hepatitis.  22(6):524-34. doi: 10.1111/jvh.12355. Epub 2014 Nov 10.

Uzé G. and Tavernier, J. (2015) High efficiency targeting of IFN-α activity: possible applications in fighting tumors and infections. Cytokine and Growth Factor Reviews. 26(2):179-82. doi: 10.1016/j.cytogfr.2014.10.006

Wilmes S., Beutel O., Li Z., Franҫois-Newton V., Richter C.P., Janning D., Kroll C., Hanhart P., Hötte K., You C., Uzé G., Pellegrini S.and Piehler J. (2015) Receptor dimerization dynamics as regulatory valve for plasticity of type I interferon signalling. J. Cell Biol. 209: 579-593.

Paul F., Pellegrini S. and Uzé G. IFNA2: The prototypic human alpha interferon. (2015) Gene. 567: 132-137.

Livingstone M., Sikström K., Robert P.A., Uzé G., Larson O. and Pellegrini S. Assessment of mTOR-dependent translational regulation of interferon stimulated genes. (2015) PLos One. 10(7): e0133482.

 

Equipe Bernard LEBLEU

Boisguérin P., Deshayes S., Gait MJ., O'Donovan L., Godfrey C., Betts CA., Wood MJ., Lebleu B.  Adv Drug Deliv Rev. Delivery of therapeutic oligonucleotides with cell penetrating peptides (2015).  Jun 29;87:52-67.

Boisguerin P., O'Donovan L., Gait MJ., Lebleu B. Methods Mol Biol. In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy. (2015) 1324:317-29.

 

- 2014 -

Equipe 1

Penarete-Vargas DM., Boisson A., Urbach S., Chantelauze H., Peyrottes S., Fraisse L., Vial HJ. (2014) A Chemical Proteomics Approach for the Search of Pharmacological Targets of the Antimalarial Clinical Candidate Albitiazolium in Plasmodium falciparum Using Photocrosslinking and Click Chemistry. PLoS One, 9(12):e113918. doi: 10.1371.

Nagy GN., Marton L., Contet A., Ozohanics O., Ardelean LM., Révész A., K Vékey K., Irimie FD.,  Vial H., Cerdan R., Vertessy BG. (2014) Composite aromatic box: a structural motif for binding and enzyme-catalyzed conversion of quaternary ammonium substrates, Angew Chem Int Ed Engl. 53(49):13471-6. doi: 10.1002/anie.201408246; PMID: 25283789

Vial H., and Wengelnik K. (2014) Phospholipid metabolism, Encyclopedia of Malaria, (M Hommel and PG Kremsner Edit),  Springer Press

Vial H.J., and Wengelnik K. (2014). Phospholipid metabolism. In Encyclopedia of Malaria, edited by Marcel Hommel and Peter G. Kremser, Springer. Electronic and printed version expected in 2017.

Wein S., Tran Van Ba C., Maynadier M., Y. Bordat., Perez J., Peyrottes S., Fraisse L. & Vial HJ. (2014) New insight in the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium - a new type of antimalarial. Antimicrobial Agents and Chemotherapy, 58(9), 5519-5527.

Ruiz J., Azémaa J., Payrastre C., Baltas M., Tuccio B., Vial H., André-Barrès C. (2014)  Antimalarial bicyclic peroxides belonging to the G-factor family: mechanistic aspects of their formation and iron (II) induced reduction, Current Topics in Medicinal Chemistry, 14(14):1668-1683; PMID: 25116578, ISSN: 1568-0266

Peyrotte S., Caldarelli S., Wein S., Périgaud C., and Vial H. (2014) Exploring prodrug approaches for Albitiazolium and its analogues, Current Topics in Medicinal Chemistry ;14(14):1653-1667; PMID: 25116583, ISSN: 1568-0266

Ruiz J., Mallet-Ladeira S., Maynadier M., Vial H. and André-Barrès C. (2014) Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents. Org Biomol Chem. 12(28):5212-21

Saidani N., Botte C., Deligny M., Bonneau AL., Reader J., LasselinR., Merer G., Niepceron A.,  Brossier F., Cintrat J.C., Rousseau B., Birkholtz LM., Cesbron-Delauw MF., Dubremetz JF., Mercier C., Vial H., Lopez R., and Marechal E. (2014) Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolidinone analogs, Antimicrob. Agents Chemother 58(5):2586. DOI: 10.1128/AAC.01445-13, PMID: 24550329

Degardin M., Wein S., Duckert JF., Maynadier M., Guy A., Durand T., R Escale R., Vial H. and Vo-Hoang Y.  (2014)Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs., ChemMedChem.  9:300-4. doi: 10.1002/cmdc.201300419; PMID: 24403182.

Lamarque MH., Roques M., Kong-Hap M., Tonkin ML., Rugarabamu G., Marq JB., Penarete-Vargas DM., Boulanger MJ., Soldati-Favre D., Lebrun M.  (2014) Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites. Nat Commun.  Jun 17;5:4098. 

Morlon-Guyot J., Berry L., Chen CT., Gubbels MJ., Lebrun M., Daher W. (2014) The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell Microbiol. 95-114.

Salamun J., Kallio J., Daher W., Soldati-Favre D., and Kursula I. (2014) Structure of Toxoplasma gondii coronin: an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. FASEB Journal, 4729-4747.

Nguyen-Chi M., Phan QT., Gonzalez C., Dubremetz JF., Levraud JP., Lutfalla G. (2014) Transient infection of the zebrafish notochord with E. coli induces chronic inflammation. Dis Model Mech.  Jul;7(7):871-82. 

Bernut A., Herrmann JL., Kissa K., Dubremetz JF., Gaillard JL., Lutfalla G., Kremer L.  (2014) Proc Natl Acad Sci U S A. Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation.  Mar 11;111(10)

Saïdani N., Botté CY., Deligny M., Bonneau AL., Reader J., Lasselin R., Merer G., Niepceron A., Brossier F., Cintrat JC., Rousseau B., Birkholtz LM., Cesbron-Delauw MF., Dubremetz JF., Mercier C., Vial H., Lopez R., Maréchal E.  (2014) Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother.  May;58(5):2586-97.

Niehus S., Smith TK., Azzouz N., Campos MA., Dubremetz JF., Gazzinelli RT., Schwarz RT., Debierre-Grockiego F.  (2014) Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages. PLoS One.  Jan 28;9(1):e85386. 

Fond G., Macgregor A., Tamouza R., Hamdani N., Meary A., Leboyer M., Dubremetz JF.  (2014) Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. Eur Arch Psychiatry Clin Neurosci.  Mar;264(2):179-83.

 

Equipe 2

Baïlo N., Cosson P., Charette S.J., Paquet V.E., Doublet P., Letourneur F. (2014) Defective lysosome maturation and Legionella pneumophila replication in Dictyostelium cells mutant for the Arf GAP ACAP-A. J Cell Sci. Nov 1;127(21):4702-13. doi: 10.1242/jcs.154559. Epub 2014 Sep 4. PMID: 25189617.

Belon C., Gannoun-Zaki L., Lutfalla G., Kremer L., Blanc-Potard A. (2014) Mycobacterium marinum MgtC plays a role in phagocytosis but is dispensable for intracellular multiplication. PLoSOne.29;9(12):e116052.doi:10.1371/journal.pone.0116052. eCollection.

Gannoun-Zaki L., Belon C., Dupont C., Hilbert F., Kremer L., Blanc-Potard A. (2014).Overexpression of the Salmonella KdpF membrane peptide modulates expression of kdp genes and intramacrophage growth. FEMS Microbiol Lett. 359(1):34-41. doi: 10.1111/1574-6968.12559. Epub 2014 Sep 8.

Alibaud L., Pawelczyk J., Gannoun-Zaki L., Singh VK., Rombouts Y., Drancourt M., Dziadek J., Guérardel Y., Kremer L. (2014) Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study. J Biol Chem. 3;289(1):215-28. doi: 10.1074/jbc.M113.525550. Epub 2013 Nov 14.

Canova M.J., and Molle V. (2014) Bacterial Serine/Threonine Protein Kinases in Host-Pathogen Interactions. J Biol Chem. 289:9473-79.
Leiba J., Carrère-Kremer S., Blondiaux N., Dimala M.M., Wohlkönig A., Baulard A., Kremer L., and  Molle V. (2014) The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation. Biochem Biophys Research Commun 446:1132-1138.

Canova M.J., Baronian G., Brelle S., Cohen-Gonsaud M., Bischoff M., and Molle V. (2014) A novel mode of regulation of the Staphylococcus aureus Vancomycin-resistance-associated response regulator VraR mediated by Stk1 protein phosphorylation. Biochem Biophys Research Commun 447:165-171.

Vilchèze C., Molle V., Carrère-Kremer S., Leiba J., Mourey L., Shenai S., Baronian G., Tufariello J.,   Hartman T., Veyron-Churlet R., Trivelli X., Tiwari S., Weinrick B., Alland D., Guérardel Y., Jacobs W.R., Jr., and Kremer L. (2014) Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis. Plos Pathogens 8:10(5):e1004115.

Hartmann T., Baronian G., Nippe N., Voss M., Schulthess B., Wolz C., Eisenbeis J., Schmidt-Hohagen K., Gaupp R., Sunderkötter C., Beisswenger C., Bals R., Somerville G.A., Herrmann M., Molle V., and Bischoff M. (2014) The catabolite control protein E (CcpE) affects virulence determinant production and pathogenesis of Staphylococcus aureus. J Biol Chem 289:29701-29711.

Mouammine, Lanois A., Pagès S., Lafay B., Molle V., Canova M., Girard P.A., Duvic B., Givaudan A. and Gaudriault S. (2014) Ail and PagC-related proteins in the entomopathogenic bacteria of Photorhabdus genus. PLoS One 9:e110060.

Arora G., Sajid A., Singhal A., Joshi J., Virmani R., Gupta M., Verma N., Maji A., Misra R., Baronian G., Pandey A.K., Molle V. and Singh Y. (2014) Identification of Ser/Thr kinase and forkhead associated domains in Mycobacterium ulcerans: characterization of novel association between protein kinase Q and MupFHA. PLoS Neglected Tropical Diseases 8:e3315.

Holečková N., Doubravová L., Massidda O., Molle V., Buriánková K., Benada O., Kofroňová O., Ulrych A. and Branny P. (2014) LocZ is a new cell division protein involved in proper septum placement in Streptococcus pneumoniae. MBio. 6(1):e01700-14.

 

Equipe 5

Ciandrini L., Neri I., Walter J.C., Dauloudet O., Parmeggiani A., Motor protein traffic regulation by supply-demand balance of resources. Physical Biology 11 (2014), 056006-1/17, selected as the Physical Biology Highlights of 2014, http ://iopscience.iop.org/1478-3975/page/Highlights-of-2014

Rohani N., Parmeggiani A., Winklbauer R., Fagotto F. Variable Combinations of Specific Ephrin Ligand/Eph Receptor Pairs Control Embryonic Tissue Separation PLoS Biology 12 (2014), e1001955-1/21, Synopsis by R. Robinson,“Bind and Separate : How Ephrins and Their Receptors Create Tissue Boundaries”, PLoS, Biol 12 (2014), e1001956.

Ciandrini L., Romano M.C., Parmeggiani A., Stepping and crowding of molecular motors : statistical kinetics from an exclusion process perspective - Biophysical Journal 107 (2014), 1176-1184

Parmeggiani A., Neri I., Kern N. (2014) Modelling Collective Cytoskeletal Transport and Intracellular Traffic - The Impact of Applications on Mathematics - 1-25

Noel V., Grigoriev D., Vakulenko S., Radulescu O. (2014) Tropical and Idempotent Mathematics and Applications, Contemporary Mathematics vol. 616, chap. Tropicalization and tropical equilibration of chemical reactions. American Mathematical Society.

Soliman S., Fages F., Radulescu O. (2014) : A constraint solving approach to model reduction by tropical equilibration. Algorithms for Molecular Biology 9(1), 24.

 

Equipe 6

Fontenille L., Rouquier S., Lutfalla G., Giorgi D. (2014) Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell Cycle, 13 (7) 1101-1114
Bernut A., Herrmann JL., Kissa K., Dubremetz JF., Gaillard JF., Lutfalla G. and Kremer L. (2014). Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. PNAS, 111(10):E943-52.

Nguyen-Chi M., Phan QT., Gonzalez C., Dubremetz JF., Levraud JP., Lutfalla G. (2014). Transient infection of the zebrafish notochord triggers chronic inflammation. Disease Models and Mechanisms, 7(7):871-82

Siupka P., Hamming O.J., Frétaud M., Luftalla G., Levraud J.P. and Hartmann R. (2014). The crystal structure of zebrafish IL-22 reveals an evolutionary conserved structure highly similar to that of human IL-22 and IFNλ. Genes & Immunity, 15(5):293-302.

Bernut A., Le Moigne V., Lesne T., Lutfalla G., Herrmann JL., and Kremer L. (2014) In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system. Antimicrobial Agents and Chemotherapy  58:4054-63

Belon C., Gannoun-Zaki L., Lutfalla G., Kremer L. and Blanc-Potard AB (2014) Mycobacterium marinum MgtC plays a role in phagocytosis but is dispensable for intracellular multiplication. PLoS One. 2014 Dec 29;9(12):e116052

Graciarena M., Dambly-Chaudière C., Ghysen A., (2014) Dynamics of axonal regeneration in adult and aging zebrafish reveal the promoting effect of a first lesion. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1610-5. 

Duquenne C., Psomas C., Gimenez S., Guigues A., Carles MJ., Barbuat C., Lavigne JP., Sotto A., Reynes J., Guglielmi P., Mettling C., François V., Corbeau P. (2014) The two human CXCR4 isoforms display different HIV receptor activities: consequences for the emergence of X4 strains. J Immunol. 2014 Oct 15;193(8):4188-94. 

Hamze M., Desmetz C., Guglielmi P. (2014) B lymphocytes: a promising target to treat atherosclerosis? Med Sci (Paris). 2014 Oct;30(10):874-81.

 

Equipe 7

Faucherre A., Kissa K., Nargeot J., Mangoni ME., Jopling C. (2014). Piezo1 plays a role in erythrocyte volume homeostasis. Haematologica. Jan; 99 (1):70-5.

 

Equipe 8

Garcin G., Paul F., Staufenbiel, M., Bordat Y., Van der Heyden, J., Wilmes, S., Cartron G.,4, Apparailly, F., De Koker, S., Piehler, J., Tavernier, J. and Uzé G. (2014) High efficiency cell−specific targeting of cytokine activity. Nature Commun. 5:3016 doi: 10.1038/ncomms4016.

Sistigu  A., Yamazaki T., Vacchelli E., Chaba K., Enot D.P., Adam J., Vitale I., Goubar A., Baracco E.E., Remédios C., Fend L., Hannani D., Aymeric L., Ma Y., Niso-Santano M., Kepp O., Schultze J.L., Tüting T., Belardelli F., Bracci L., La Sorsa V., Ziccheddu G., Sestili P., Urbani F., Delorenzi M., Lacroix-Triki  M., Quidville V., Conforti R., Spano J-P., Pusztai L., Poirier-Colame V., Delaloge, S., Penault-Llorca F., Ladoire S., Arnould L., Cyrta J., Marie-Charlotte Dessoliers M-C., Eggermont A., Bianchi M.E., Pittet M., Engblom C., Pfirschke C., Préville X., Uzé G., Schreiber R.D., Chow M.T., Smyth M.J., Proietti  E., André F., Kroemer G. and Zitvogel L. (2014) Cancer cell-autonomous contribution of Type 1 interferon signaling to the efficacy of chemotherapy. Nature Medecine. 11. 1301-1309.

Tomasello E., Pollet E., Vu-Manh T-P., Uzé G. and Dalod M. (2014) Harnessing mechanistic knowledge on beneficial versus deleterious IFN-I effects to design innovative immunotherapies targeting cytokine activity to specific cell types. Frontiers in Immunology. 5. 526.

Comet N.R., Aguiló J.I., Rathoré M.G., Catalán E., Garaude J., Uzé G., Naval J., Pardo J., Villalba M., and Anel A. (2014) IFN-α signaling through PKC-θ is essential for anti-tumoral NK cell function Oncoimmunology. 3. e948705.

Cartron G., de Guibert S., Dilhuydy MS., Morschhauser F., Leblond V., Dupuis J., Mahe B., Bouabdallah R., Lei G., Wenger M., Wassner-Fritsch E.; Hallek M. (2014) Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study.Blood. 124(14):2196-202. doi: 10.1182/blood-2014-07-586610. Epub 2014 Aug 20.

Gagez AL., Cartron G. (2014) Obinutuzumab: a new class of anti-CD20 monoclonal antibody.Curr Opin Oncol. 26(5):484-91. doi: 10.1097/CCO.0000000000000107.

Gagez AL., Cartron G. (2014) Obinutuzumab: a new class of anti-CD20 monoclonal antibody.Curr Opin Oncol. 26(5):484-91. doi: 10.1097/CCO.0000000000000107.

 

- 2013 –

Equipe 1

Vial H., Taramelli D., Boulton IC., Ward SA., Doerig C. and Chibale K., (2013), CRIMALDDI: platform technologies and novel anti-malarial drug targets, Malaria Journal, 12:396, doi: 10.1186/1475-2875-12-396, PMID: 24498961

Sen P., Vial HJ., Radulescu O. (2013) Kinetic modelling of Phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways., BMC Systems Biology, 7(1):123. doi: 10.1186/1752-0509-7-123. PMID: 24209716.

De Macêdo JP., Schmidt R., Sigel E., Rentsch D., Vial H.J.,  Mäser P. and Peter Bütikofer. (2013) Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms ; Mol Biochem. Parasit. 90, 16-22 (IF : 2.73)

Pasini E., Van den Ierssel D., Vial HJ and Kocken CMH, A novel live-dead staining methodology to study malaria parasite viability, Malaria J, 12:190. doi: 10.1186/1475-2875-12-190 ; PMID: 23758788 (IF : 3.19)

Ruiz J., Tuccio B., Lauricella R., Maynadier M., Vial H., André-Barrès C. (2013) Synthesis and antiplasmodial evaluation of cyclopropyl analogs of the G-factor bicyclic peroxide. Tetrahedron, 69, 6709-6720, (IF : 3.22)

Nagy G., Marton L., Krámos B., Oláh J., Revész A., Véky K., Delsuc F., Hunyadi-Gulyas E., Medzihradszky K., Lavigne L., Vial H., Cerdan R., Vertessy B. (2013) Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum. FEBS J. 2013, 280(13):3132-48 (IF :3.04). doi: 10.1111/febs.12282., PMID: 23578277

Traoré M., Mietton F., Maubon D.,  Peuchmaur M.,  Francisco HF., Pereira de Freitas R., Bougdour A., Curt A.,  Maynadier M., Vial H., Pelloux H., Hakimi MA., Wong YS.  (2013) Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides. J. Organic Chemistry,78, 3655-75. (IF : 4.22)

Lombard MC., N Da DD., Tran Van Ba C., Wein S., Norman J., Wiesner L., Vial H.  (2013) Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids. Malar J. 12:71. doi: 10.1186/1475-2875-12-71. PMID:  23433124, (IF : 3.19)

Caldarelli S., El Fangour S., Wein S., C. Tran van  Ba., Perigaud C., Pellet A., Vial H.,  Peyrottes S. ( 2013) New Bis-Thiazolium Analogues as Potential Anti-Malarial Agents: Design, Synthesis and Biological Evaluation, J Med Chem. 56(2):496-509; doi: 10.1021/jm3014585, PMID: 23289711(IF : 5,25)

Maheshwari S.,  Lavigne M., Alberge B., Pihan E., Kocken C., Wengelnik K., Douguet D.,  Vial H. And Cerdan R. (2013) Functional characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase, the rate-limiting step of the de novo phosphatidylethanolamine biosynthesis pathway. Biochem J., 450(1):159-67. doi: 10.1042/BJ20121480; PMID: 23198904 , (IF : 4.9)

Mbengue A., Audiger N., Vialla E., Dubremetz JF., Braun-Breton C.  (2013) Novel Plasmodium falciparum Maurer's clefts protein families implicated in the release of infectious merozoites. Mol Microbiol. 88(2): 425-42.

Kemp LE., Rusch M., Adibekian A., Bullen HE., Graindorge A., Freymond C., Rottmann M., Braun-Breton C., Baumeister S., Porfetye AT., Vetter IR., Hedberg C., Soldati-Favre D. (2013). Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii. J Biol Chem. 288(38):27002-18.

Yam XY., Birago C., Fratini F., Di Girolamo F., Raggi C., Sargiacomo M., Bachi A., Berry L., Fall G., Curra C., Pizzi E., Braun-Breton C., Ponzi M. (2013). Proteomic analysis of detergent-resistant membrane micro-domains in trophozoite blood stage of the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics 12(12):3948-61

Kong-Hap MA., Mouammine A., Daher W., Berry L., Lebrun M., Dubremetz JF., Besteiro S.  (2013) Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy. September ;9(9):1334-48

Tonkin ML., Crawford J., Lebrun ML., Boulanger MJ. (2013)  Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion. Protein Sci.  Jan;22(1):114-27

De Napoli. M.G., N. de Miguel., Lebrun M., Moreno S.N.J., Angel S.O., Corvi M.M.  (2013) N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization. 2013 Biochimica and Biophysica Acta (BBA) - Molecular Cell Research. Jun;1833(6):1329-37.

Vanagas L., Dalmasso MC., Dubremetz JF., Portiansky EL., Olins DE., Angel SO. (2013) Parasitology. Epichromatin is conserved in Toxoplasma gondii and labels the exterior parasite chromatin throughout the cell cycle. Aug;140(9):1104-10.

Mueller C., Klages N., Jacot D., Santos JM., Cabrera A., Gilberger TW., Dubremetz JF., Soldati-Favre D. (2013) The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion. Cell Host Microbe. Mar 13;13(3):289-301.

Azzouz N., Kamena F., Laurino P., Kikkeri R., Mercier C., Cesbron-Delauw MF., Dubremetz JF., De Cola L., Seeberger PH. (2013) Toxoplasma gondii secretory proteins bind to sulfated heparin structures. Glycobiology. Jan;23(1):106-20. 

Jacot D., Daher W., Soldati-Favre D. (2013) Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance. EMBO Journal, 1702-1716.

 

Equipe 2

G. D. Coxon., D. Craig., Corrales R.M., Vialla E., Gannoun-Zaki L., and Kremer L., (2013) Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues. PLOS One. 8: e53162.

Saxena A.K., Roy K.K., Singh S., Vishnoi S.P., Kumar A., Kashyap V. Kr., Kremer L., Srivastava R., and Srivastava B.S. (2013) Identification and characterization of small molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia. Int. J. Antimicrob. Agents. 42(1):27-35. doi: 10.1016/j.ijantimicag.2013.03.007. Epub 2013 May 14. 

Sambandan D.,  D. Dao, Weinrick B.C., C. Vilchèze C., Gurcha S.S., A. Ojha A., Kremer L., Besra G.S., Hatfull G.F., and Jacobs W.R., Jr. (2013) Keto-mycolic aicds-dependent pellicle formation confers tolerance to drug sensitive Mycobacteirum tuberculosis. mBio. 7;4(3):e00222-13. doi: 10.1128/mBio.00222-13. 

Leiba J., Syson K., Baronian G., Zanella-Cléon I., Kalscheuer R., Kremer L., Bornemann S., and  Molle V. (2013) Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated anti-tuberculosis target, is negatively regulated by Ser/Thr phosphorylation. J. Biol. Chem. 288(23):16546-56. doi: 10.1074/jbc.M112.398503. Epub 2013 Apr 22.

Kumar K., Carrère-Kremer S., Kremer L., Guérardel Y., Biot C., and Kumar V. (2013)  Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered ?-lactam-ferrocene and ?-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation. Dalton Trans. 42: 1492-1500.

Kumar K., Carrère-Kremer S., Kremer L., Guérardel Y., Biot C., and Kumar V. (2013) 1H-1,2,3-triazole-tethered isatin-ferrocene and isatin-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation. Organometallics. In Press.

Gannoun-Zaki L., Alibaud L., and Kremer L. (2013) Point mutations within the FAS-II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 57: 629-632.

Gannoun-Zaki L., Alibaud L., Carrère-Kremer S., Kremer L., and Blanc-Potard A.B.  (2013) Overexpression of the KdpF membrane peptide in M. bovis BCG results in reduced intramacrophage growth and altered cording morphology. PLOS One. 8: e60379

Corrales R.M., Leiba J., Cohen-Gonsaud M., Molle V., and Kremer L. (2013) Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation. Biochem. Biophys. Res. Commun. 430: 858-864.

Hartmann T., Zhang B., Baronian G., Schulthess B., Homerova D., Grubmüller S., Kutzner E., Gaupp R., Bertram R., Powers R., Eisenreich W., Kormanec J., Herrmann M., Molle V., Somerville G.A., and Bischoff M. (2013) Catabolite control protein E (CcpE) is a LysR-type transcriptional regulator of TCA cycle activity in Staphylococcus aureus. Journal of Biological Chemistry 288:36116-36128.

Wilson R., Kumar P., Parashar V., Vilchèze C., Veyron-Churlet R., Freundlich J.S., Barnes S.W., Walker J.R., Marchiano E., Shenai S., Colangeli R., Jacobs W.R., Jr., Neiditch M.B., Kremer L., and  Alland D.  (2013) Pks13 is required for mycolic acid biosynthesis in Mycobacterium tuberculosis and is specifically inhibited by a novel class of thiophene compounds. Nat. Chem. Biol. 9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16.

Y. Yang A., Bhatti D., Ke,  Gonzalez-Juarrero M., Lenaerts A., Kremer L., Guérardel Y., Zhang P., and Ojha A..K. (2013) Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J. Biol. Chem. 288: 382-392.

 

Equipe 4

Raynaud F., Janossy A., Dahl J., Bertaso F., Perroy J., Varrault A., Vidal M., Worley P., Boeckers TM., Bockaert J., Marin P., Fagni L., and Homburger V. (2013) Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-term Potentiation. J. Neuroscience 33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013.

 

Equipe 5

Raguin A.,  Parmeggiani A., Kern N. (2013) Role of network junctions for the totally asymmetric simple exclusion process Physical Review E 88 - 042104-1/15

Neri I., Kern N., Parmeggiani A. (2013) Exclusion processes on networks as models for cytoskeletal transport New Journal of Physics 15 -  085005-1/54 ; Focus on Soft Mesoscopics : Physics for Biology at a Mesoscopic Scale

Fargier G., Favard C., Parmeggiani A., Sahuquet Q., Mérezègue F., Morel A., Denis M., Molinari N., Mangeat P.H., Coopman P.J., Montcourrier P.I. (2013) Centrosomal targeting of Syk kinase is controlled by its catalytic activity and depends on microtubules and the dynein motor, FASEB J. 27 109-122;

Neri I., Kern N., Parmeggiani A. (2013) Modelling intracellular traffic : an interplay between passive diffusion and active transport,Phys. Rev. Lett. Phys. Rev. Lett. 110. 098102;

Turci F., Parmeggiani  A., Pitard E., Romano  M. C., Ciandrini  L.,  (2013) Transport on a Lattice with Dynamical Defects, Phys. Rev. E 87. 012705-1/8 

Innocentini G.C.P., Forger M., Ramos A.F., Radulescu O., Hornos J.E.M. (2013) Multi-modality and flexibility of stochastic gene expression. Bulletin of Mathematical Biology, 75:2600-30.

Noel V., Vakulenko S., Radulescu O.  (2013) A hybrid mammalian cell cycle model. Electronic Proceedings in Theoretical Computer Science - 125: 68-83.

Sen P., Vial H.J., Radulescu O. (2013) Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways. BMC Systems Biology, 7:123.

 

Equipe 6

Hamze M., Desmetz C., Guglielmi P. (2013) B cell-derived cytokines in disease. Eur Cytokine Netw. Mar 1;24(1):20-6.

Palha N., Guivel-Benhassine F., Lutfalla G., Sourisseau M., Herbomel P., Schwartz O., Levraud J.P. (2013) Real-time whole-body visualization of Chikungunya virus infection and host interferon response - Plos Pathogen 9(9):e1003619. doi: 10.1371/journal.ppat.1003619. Epub 2013 Sep 5.

Wada H., Dambly-Chaudière C., Kawakami K., Ghysen A. (2013) Innervation is required for sense organ development in the lateral line system of adult zebrafish. Proc Natl Acad Sci U S A. Apr 2;110(14):5659-64. 

Hamze M., Desmetz C., Berthe ML., Roger P., Boulle N., Brancherau P., Picard E., Guzman C., Tolza C., Guglielmi P. (2013) Characterization of resident B cells of vascular walls in human atherosclerotic patients. J Immunol. 2013 Sep 15;191(6):3006-16. 

Chen YC., Tien YJ., Chen CH., Beltran FN., Amor EC., Wang RJ., Wu DJ., Mettling C., Lin YL., Yang WC. (2013) Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling. BMC Complement Altern Med. 2013 Feb 23;13:45.

 

Equipe 7

Demy DL., Ranta Z., Giorgi JM., Gonzalez M., Herbomel P., Kissa K. (2013) Generating parabiotic zebrafish embryos for cell migration and homing studies. Nat Methods. 10:256-8.

 

Equipe 8

Uzé G., (2013) Interféron et immunité anticancéreuse. In Thérapie ciblée des cancers. Les cibles de l'immunité. Vol 8, JohnLibbey Eurotext Ed. pp 34−43.*

Bachy E., Houot R., Morschhauser F., Sonet A., Brice P., Belhadj K., Cartron G., Audhuy B., Ferme C., Feugier P., Sebban C., Delwail V., Maisonneuve H., Le Gouill S., Lefort S., Brousse N., Foussard C., and Salles G.  (2013) Long-term follow-up of the FL2000 studycomparing CHVP-interferon to CHVP-interferon plus rituximab in follicular lymphoma.Haematologica.  98(7):1107-14. doi: 10.3324/haematol.2012.082412. Epub 2013 May 3.

Garcin G., Bordat Y., Chuchan P., Monneron D., Law H.K.W., Piehler J. and Uzé G.  (2013) Differential activity of type I interferon subtypes for dendritic cell differentiation. PloS One. (20138(3) : e58465 (IF 4.09)

Morschhauser F., Cartron G., Solal-Céligny P., Haioun C., Bouabdallah R., Feugier P., Bouabdallah K., Asikanius E., Lei G., Wenger M., Wassner-Fritsch E., Salles GA. (2013) Obinutuzumab (GA101) Monotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma or Mantle Cell Lymphoma: Results From the Phase II GAUGUIN Study.J Clin Oncol. In Press. (IF 18.37)

Salles GA., Morschhauser F., Solal-Céligny P., Thieblemont C., Lamy T., Tilly H., Gyan E., Lei G., Wenger M., Wassner-Fritsch E., and Cartron G. (2013) Obinutuzumab (GA101) in Patients With Relapsed/Refractory Indolent Non-Hodgkin’s Lymphoma: Results of the Phase II GAUGUIN Study J Clin Oncol. In Press. 31(23):2920-6. doi: 10.1200/JCO.2012.46.9718. Epub 2013 Jul 8.

 

 

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