dimnp

Cytokines, evolution and the onset of immunity

geogrs lutfalla Responsable :

Georges LUTFALLA (DR CNRS)

 

 

 

 

 

 

 

Team

DAMBLY-CHAUDIERE Christine

Professor UM emerite

christine.dambly-chaudiere arobase umontpellier.fr

GONZALES Catherine

TCN CNRS

catherine.gonzales arobase umontpellier.fr

GUGLIELMI Paul

DR INSERM emerite

paul.guglielmi arobase umontpellier.fr 

LUTFALLA Georges

DR CNRS

georges.lutfalla arobase umontpellier.fr

NGUYEN CHI Mai
CR CNRS
mai.chi-nguyen arobase umontpellier.fr
PECIAROVA Veronika
EU Project manager
veronika.peciarova arobase umontpellier.fr

ROUSSEL Jean-Paul

MCF UM

jean-paul.roussel arobase umontpellier.fr

SIPKA Tamara DOCTORANT tamara.sipka arobase umontpellier.fr

YATIME Laure

CR1 INSERM

laure.yatime arobase umontpellier.fr

 

Tamara Sipka has been recruited in the frame of Marie Sklodowska-Curie ITN project "ImageInLife" (GA N°721537). 

 
 
The main interest of the laboratory is to understand the molecular and cellular interplays that orchestrate host pathogen interactions in vertebrates.
 

Project 2: Receptors from the immunoglobulin superfamily and their role in chronic inflammation
Contact Dr. Laure YATIME

We are studying several sub-classes of receptors from the immunoglobulin superfamily involved in the maintenance of chronic inflammation during cancer or infection. More specifically, we are looking at receptors that are activated by either endogenous or pathogenic danger molecules and we try to elucidate how the recognition of these ligands by their cognate receptors triggers a pro-inflammatory response that facilitates disease progression in various pathological contexts. For that purpose, we apply a multidisciplinary approach combining biochemistry, structural biology and in vivo modeling in zebrafish.

Project 3:
Contact Dr. Paul GUGLIELMI

Project 4: Intron dynamics
Contact Dr. Georges LUTFALLA and Dr. Clement METTLING

Introns are hallmarks of metazoan genes, but their role during genome evolution is debated: Selfish? Exon shuffling? Their conserved positions in most species demonstrate their high stability. The existence of independent animal groups escaping this rule suggests that introns can move and that other metazoans including mammals have active mechanisms preventing intron dynamics.
    According to the theory of Walter Gilbert, intron dynamics is mediated by homologous recombination involving reverse transcribed (RT) cDNAs. We are studying genome dynamics in a mouse model accumulating RT products where we observe specific intron loss events.
   To our knowledge, this is the first available experimental animal model to study intron dynamics. The aim of the proposal is to characterize intron loss events in this mutant mouse line to enlighten the controversy on the stability of introns and more generally study genome dynamics in the presence of accumulating reverse transcription product.

Read also: The interferon system in zebrafish.
Ribosomes Biogenesis.